With an area of 447,000 square kilometers (approximately the size of France or California), Uzbekistan stretches 1,425 kilometers from west to east and 930 kilometers from north to south. Bordering Turkmenistan to the southwest, Kazakstan to the north, and Tajikistan and Kyrgyzstan to the south and east, Uzbekistan is not only one of the larger Central Asian states but also the only Central Asian state to border all of the other four. Uzbekistan also shares a short border with Afghanistan to the south.

Uzbekistan is a dry, double-landlocked country of which 10% consists of intensely cultivated, irrigated river valleys. It is one of two double-landlocked countries in the world - the other being Liechtenstein, although in the case of Uzbekistan this is less clear, since it has borders with two countries (Kazakhstan in the north and Turkmenistan in the south) bordering the landlocked but non-freshwater Caspian Sea from which ships can reach the Sea of Azov and thus the Black Sea, the Mediterranean Sea and the oceans.

The highest point in Uzbekistan is Adelunga Toghi at 4301 meters.